Simone Hettmer Selected Research

sinbaglustat

7/2003

Inhibition of melanoma tumor growth by a novel inhibitor of glucosylceramide synthase.

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Simone Hettmer Research Topics

Disease

25	Neoplasms (Cancer) 01/2022 - 07/2003
6	Sarcoma (Soft Tissue Sarcoma) 01/2021 - 12/2011
5	Rhabdomyosarcoma 01/2020 - 12/2011
2	Melanoma (Melanoma, Malignant) 01/2022 - 07/2003
2	Disease Progression 01/2021 - 11/2013
2	Neuroblastoma 07/2005 - 11/2003
1	Respiratory Insufficiency (Respiratory Failure) 01/2022
1	Melanosis (Freckles) 01/2022
1	Cytomegalovirus Infections (Inclusion Disease) 01/2022
1	Pigmented Nevus (Melanocytic Nevus) 01/2022
1	Rhabdoid Tumor (Rhabdoid Tumors) 12/2021
1	Hematologic Neoplasms (Hematological Malignancy) 12/2021
1	Aggressive Fibromatosis (Desmoid) 01/2021
1	Fibroma (Fibromatosis) 01/2021
1	COVID-19 12/2020
1	Fibrosarcoma 01/2020
1	Adenoma (Adenomas) 01/2020
1	Genetic Translocation (Chromosomal Translocation) 11/2014
1	Metabolic Diseases (Metabolic Disease) 07/2014
1	Obesity 07/2014
1	Embryonal Rhabdomyosarcoma 06/2013
1	Myeloid Sarcoma (Chloroma) 01/2012
1	Leukemia 01/2012
1	Histiocytic Sarcoma 01/2012
1	Neutropenia 11/2008
1	Aneuploidy (Aneuploid) 11/2003

Drug/Important Bio-Agent (IBA)

4	Phosphotransferases (Kinase)IBA 01/2020 - 11/2013
3	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 11/2003
3	Biological ProductsIBA 12/2021 - 11/2003
3	GangliosidesIBA 07/2005 - 07/2003
2	AsparagineIBA 01/2021 - 10/2015
2	Aspartic Acid (Aspartate)FDA Link 01/2021 - 10/2015
2	Tyrosine Kinase InhibitorsIBA 01/2021 - 11/2013
2	Sirolimus (Rapamycin)FDA Link 01/2018 - 12/2011
2	Calcium Gluconate (CBG)IBA 07/2005 - 11/2003
1	Mitogen-Activated Protein Kinase 1 (p42 MAP Kinase)IBA 01/2022
1	trametinibIBA 01/2022
1	MethyltransferasesIBA 01/2022
1	Azacitidine (5 Azacytidine)FDA Link 01/2022
1	Codon (Codons)IBA 01/2022
1	Mitogen-Activated Protein KinasesIBA 01/2022
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2022
1	Decitabine FDA Link 12/2021
1	larotrectinibIBA 02/2021
1	entrectinibIBA 02/2021
1	Glutamine (L-Glutamine)FDA Link 01/2021
1	Essential Amino AcidsIBA 01/2021
1	Amino Acids FDA Link 01/2021
1	Tricarboxylic AcidsIBA 01/2021
1	Methotrexate (Mexate)FDA LinkGeneric 01/2021
1	Oncogene Proteins (Oncogene Protein)IBA 01/2021
1	Vinblastine (Vinblastine Sulfate)FDA Link 01/2021
1	Sorafenib (BAY 43-9006)FDA Link 01/2020
1	TropomyosinIBA 01/2020
1	latrunculin A (LAT-A)IBA 01/2020
1	Oxygen (Dioxygen)IBA 01/2020
1	Proteins (Proteins, Gene)FDA Link 01/2020
1	Biomarkers (Surrogate Marker)IBA 01/2018
1	Forkhead Box Protein O1IBA 01/2018
1	Lenalidomide (CC 5013)FDA Link 12/2017
1	Tamoxifen FDA LinkGeneric 01/2016
1	Peptides (Polypeptides)IBA 10/2015
1	Aspartate-Ammonia Ligase (Asparagine Synthetase)IBA 10/2015
1	Asparaginase (Elspar)FDA Link 10/2015
1	Histone Deacetylase InhibitorsIBA 07/2014
1	entinostat (MS 275)IBA 07/2014
1	Mechanistic Target of Rapamycin Complex 2IBA 07/2014
1	tyrosine receptor (receptor, tyrosine)IBA 11/2013
1	Platelet-Derived Growth FactorIBA 11/2013
1	Insulin-Like PeptidesIBA 11/2013
1	Therapeutic UsesIBA 06/2013
1	Tosylphenylalanyl Chloromethyl Ketone (TPCK)IBA 06/2013
1	2- (2- amino- 3- methoxyphenyl)- 4H- 1- benzopyran- 4- oneIBA 06/2013
1	MyogeninIBA 12/2011
1	Differentiation AntigensIBA 12/2011
1	DesminIBA 12/2011
1	Cyclin-Dependent Kinase Inhibitor p16IBA 12/2011
1	Cefepime (Maxipime)FDA LinkGeneric 11/2008
1	Tumor Biomarkers (Tumor Markers)IBA 11/2003
1	Ferritins (Ferritin)IBA 11/2003
1	GD1b gangliosideIBA 11/2003
1	SugarsIBA 07/2003
1	ceramide glucosyltransferaseIBA 07/2003
1	Glucosylceramides (Glucocerebrosides)IBA 07/2003
1	GlycosphingolipidsIBA 07/2003
1	sinbaglustatIBA 07/2003

Therapy/Procedure

12	Therapeutics 12/2021 - 11/2013
3	Investigational Therapies (Experimental Therapy) 01/2022 - 12/2020
3	Drug Therapy (Chemotherapy) 01/2022 - 01/2014
2	Combined Modality Therapy 01/2022 - 01/2020
1	Surgical Portasystemic Shunt (Portosystemic Shunt) 01/2020
1	Morcellation 10/2019
1	Combination Drug Therapy (Combination Chemotherapy) 12/2017
1	Intramuscular Injections 01/2012
1	Transplantation 01/2012